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The UC Berkeley Center for the Science of Psychedelics BCSP Reduced extrastriate visual cortex activation during the time range of the N170 also identifies it as a potential key component of 5-HT2A agonist–induced visual hallucinations. The most salient behaviors induced in rodents by psychedelics generally have been shown due to activation of the 5-HT2A receptor. Nevertheless, higher doses of particular psychedelics may lead to activation of the 5-HT2C receptor, which often functionally opposes the effects of 5-HT2A receptor activation. For example, low doses of DOI increase locomotor activity in mice, whereas higher doses attenuate it, leading to an inverted U type of dose-response curve. For example, Shu et al. demonstrated that operation of local cortical circuits could generate activity that exhibited a proportional increase in feedback excitation and inhibition, keeping the network in relative balance. It would be most interesting to carry out a similar experiment, but with th...